Hello Jason,
Some possible matches for you:
In our Harmon Greathouse 1750 and Mary Ann family we have Homer Greathouse, no wife listed, son of Joseph V. Greathouse of Wetzel WV and Mary Carpenter
In Jacob Greathouse of Ga we have Homer Greathouse born 1885 son of Green H. Greathouse of AL and Mary Whatley
In our John Greathouse and Sarah McDade we have L. Homer Greathouse born 1889, son of James K Greathouse of Jackson WV and Virginia Argabrite
We have other Homers, with known wives, not name of Mary.
There are a number of Bucks in the John Greathouse and Sarah family and they are centered in West VA, which might be a research clue.
We have lots of active researchers in that family line including our webmaster Rick Greathouse.